| 1 |
Fujimoto M, Nakano Y, Hirano K, Onishi T, Ando H, Ohashi H, Satake A, Waseda K, Takahashi H, Amano T. Triglyceride deposit cardiomyovasculopathy as a predictor of vascular failure after coronary intervention in patients with hemodialysis: a preliminary analysis. Ren Fail 2026; 48(1):2650580. |
| 2 |
Chishaki S, Amemiya K, Kamakura T, Ikeda Y, Sakata Y, Kusano K. Delineation of ventricular tachycardia isthmus using magnetic resonance imaging in a patient with idiopathic triglyceride deposit cardiomyovasculopathy. HeartRhythm Case Rep 2025; 11(12):1363-1368. |
| 3 |
Ono R, Hoshi K, Miyauchi H, Kobayashi Y. Visual Differentiation Between Triglyceride Deposit Cardiomyovasculopathy and Old Myocardial Infarction Using Count-Washout Rate Polar Map in Iodine-123-β-Methyl-p-Iodophenyl-Pentadecanoic Acid Scintigraphy. Ann Nucl Cardiol 2025; 11(1):20-25. |
| 4 |
Hirano K, Miyauchi H, Nakajima K. Diagnostic Principle with Washout Rate of 123I-β-methyl-p-iodophenyl pentadecanoic Acid for Triglyceride Deposit Cardiomyovasculopathy. Ann Nucl Cardiol 2025; 11(1):39-41. |
| 5 |
Nakano T, Ikenaga H, Hirano K, Shigehara M, Osawa A, Morita Y, Higashihara T, Watanabe N, Sada Y, Nakano Y. Integrated Backscatter Intravascular Ultrasound Features of Diffuse Coronary Artery Disease with Triglyceride-deposit Atherosclerosis. J Investig Med 2025; Oct 24:10815589251393918. doi: 10.1177/10815589251393918. Online ahead of print. |
| 6 |
Hirano K, Okamura S, Sugimura K, Miyauchi H, Nakano Y, Nochioka K, Hashimoto C, Iwanaga Y, Nakajima K, Yamaguchi S, Yasui Y, Shimamoto S, Hirano M, Okune M, Nishimura Y, Shimoyama H, Nagasawa Y, Amano T, Kuniyoshi S, Hui SP, Zaima N, Ikeda Y, Yamada T, Fujimoto S, Sakata Y, Kobayashi K. Long-term survival and durable recovery of heart failure in patients with triglyceride deposit cardiomyovasculopathy treated with tricaprin. Nat Cardiovasc Res. 2025; 4(3):266-274. |
| 7 |
Nagasawa Y, Okamura S, Nishimura Y, Yamada T, Miyauchi H, Nakano Y, Amano T, Kawaguchi Y, Fujimoto S, Hirano K; Japan TGCV study group. Chronic kidney disease is a major risk factor for mortality in triglyceride deposit cardiomyovasculopathy patients. Clin Exp Nephrol 2025; 29(6):866-871. |
| 8 |
Kamba T, Yanagawa M, Shimamura K, Yamaguchi S, Shirakura K, Okamura S, Nishimura Y, Yamada T, Sakata Y, Tomiyama N, Miyagawa S, Hirano K, Zaima N. First-in-human abdominal aortic aneurysms trial with tricaprin (F-HAAAT): study design and protocol. CJC Open 2025; 7(2):221-230. |
| 9 |
Yamamoto H, Ikeda Y, Satomi K, Hirano KI. Acute Coronary Syndrome in a 40-Year-Old Man with Triglyceride Deposit Cardiomyovasculopathy: A Case Report. CJC Open 2024; 6(9):1116-1120. |
| 10 |
Ikeda Y, Shiba M, Yamamoto H, Itoh T, Okumura T, Nakano Y, Miyauchi H, Ide T, Yamada S, Hao H, Kato S, Hirano K. Distinct myocardial triglyceride lipolysis pathways in primary and idiopathic triglyceride deposit cardiomyovasculopathy. ESC Heart Fail 2024; 11:1275-1278. |
| 11 |
Nakano Y, Hirano K, Onishi T, Ando H, Amano T. Prevalence of TGCV among patients with acute coronary syndrome. Eur Heart J: Acute Cardiovasc Care. 2024;13: 293-295. |
| 12 |
Hirano K, Kodama K, Miyauchi H, Nagasawa Y, Nakano Y, Matsunaga M, Amano T, Nakajima K; Japan TGCV Study Group. Carnitine Administration and 123I-BMIPP Washout Rate in Hemodialysis Patients with Triglyceride Deposit Cardiomyovasculopathy. Ann Nucl Cardiol 2024;10(1):38-42. |
| 13 |
Miyauchi H, Ono R, Iimori T, Sawada K, Hoshi K, Hirano K, Kobayashi Y. Modified algorithm using total count for calculating myocardial washout rate in single-photon emission computerized tomography. Ann Nucl Cardiol 2023; 9: 19-25. |
| 14 |
Nakajima K, Miyauchi H, Hirano K, Fujimoto S, Kawahito M, Iimori T, Kudo T. Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images. Ann Nucl Med 2024; 38(1)1-8. |
| 15 |
Hirano K, Miyauchi H, Nakano Y, Kawaguchi Y, Okamura S, Nishimura Y, Onishi T, Fujimoto S, Yamada T, Amano T. Overall survival rate of patients with triglyceride deposit cardiomyovasculopathy. JACC:Advances 2023; 2 (4):100347. |
| 16 |
Nakano T, Ikenaga H, Takeda A, Morita Y, Higashihara T, Watanabe N, Sadata Y, Nakano Y. Intravascular ultrasound features of coronary artery disease with triglyceride deposit atherosclerosis. Am J Cardiol 2023; 206: 105-107. |
| 17 |
Aikawa T, Sai E, Kudo A, Kawaguchi Y, Takamura K, Hiki M, Yokoyama T, Miyazaki T, Fujimoto S, Shimada K, Hirano K, Daida H, Minamino T. 1H-MRS to Evaluate Improved Triglyceride Accumulation in Idiopathic Triglyceride Deposit Cardiomyovasculopathy after CNT-01 (Tricaprin) Administration. Endocrinol Diabetes Metab Case Rep 2023; (2):22-0370. |
| 18 |
Yamamoto M, Sato K, Murakoshi N, Yamada Y, Nakagawa D, Nakatsukasa T, Ishizu T, Ieda M. Additional diagnostic value of electron microscopic examination in endomyocardial biopsy in patients with suspected non-ischemic cardiomyopathy. J Cardiol 2023; 81(2):236-243. |
| 19 |
Satake A, Nakano Y, Niwa T, Ando H, Takashima H, Amano T. Rheocarna® as an alternative therapeutic option for patients with chronic limb-threatening ischemia: A case report. SAGE Open Med Case Rep 2023; doi: 10.1177/2050313X221149359. eCollection 2023. |
| 20 |
Hara Y, Ikeda Y, Kimura H, Shimamoto S, Ishikawa M, Kobayashi K, Nagasaka H, Shimoyama H, Hirano K. A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy. Mol Genet Metab Rep 2023; 34:100960. |
| 21 |
Hirano K, Higashi M, Nakajima K. Remarkable regression of diffuse coronary atherosclerosis in patients with triglyceride deposit cardiomyovasculopathy. Eur Heart J 2023;44(13):1191. |
| 22 |
Chen Z, Nakajima K, Hirano K, Kamiya T, Yoshida S, Saito S, Kinuya S. Methods of calculating 123I-β-methyl-P-iodophenyl-pentadecanoic acid washout rates in triglyceride deposit cardiomyovasculopathy. Ann Nucl Med 2022; 36(11):986-997. |
| 23 |
Swamy MMM, Zubir MZM, Mutmainah, Tsuboi S, Murai Y, Monde K, Hirano K, Jin T. A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice. Analyst 2022; 147(19):4206-4212. |
| 24 |
Miyauchi H, Hirano K, Nakano Y, Shimada K, Nishikawa M, Yamamoto H, Nakamura A, Miyake A, Aoshima C, Fujimoto S, Nakatani D, Yamada T, Amano T, Nakajima K. 123I-BMIPP scintigraphy shows that CNT-01(tricaprin) improves myocardial lipolysis in patients with idiopathic triglyceride deposit cardiomyovasculopathy: First randomized controlled, exploratory trial for TGCV. Ann Nucl Cardiol 2022; 8(1):67-75. |
| 25 |
Aoshima C, Fujimoto S, Kudo A, Kawaguchi Y, Takamura K, Matsue Y, Kato T, Kawamura Y, Kimura S, Kamo Y, Nozaki Y, Takahashi D, Tomizawa N, Hiki M, Kasai T, Nojiri S, Miyauchi H, Hirano K, Shimada K, Murakami K, Minamino T. Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure. Eur J Nucl Med Mol Imaging 2022; 49(9): 3129-3139. |
| 26 |
Nagasawa Y, Okumura T, Hara Y, Kondo T, Hasegawa M, Ikeda Y, Murohara T, Hirano K. Genetic deficiency of adipose triglyceride lipase is associated with a novel type of podocytopathy. Kidney International Reports 2021; 6:2722-2725. |
| 27 |
Sugawara R, Sugiyama H, Nakamura K, Tohgi K, Hongo T, Tsuchiya M, Momoki N, Nose S, Yutani C, Ikeda Y, Ikeda T, Ito H. Electron Microscopy Revealed Massive Lipid Droplets in Cardiomyocytes in a Patient with Cardiogenic Shock Following a Fulminant Type 1 Diabetes Mellitus. Int Heart J 2021; 62(1):197-200. |
| 28 |
Noguchi H, Yamada S, Hirano K, Yamaguchi S, Suzuki A, Guo X, Zaima N, Li M, Kobayashi K, Ikeda Y, Nakayama T, Sasaguri Y. Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice. Histol Histopathol 2021; 36:91-100. |
| 29 |
Nakajima K. Triglyceride deposit cardiomyovasculopathy: how to recognise a new disease entity. Heart 2021; 107(2):93-95. |
| 30 |
Sai E, Shimada K, Aikawa T, Aoshima C, Takamura K, Hiki M, Yokoyama T, Miyazaki T, Fujimoto S, Konishi H, Hirano K, Daida H, Minamino T. Triglyceride Deposit Cardiomyovasculopathy with Massive Myocardial Triglyceride which was Proven Using Proton-magnetic Resonance Spectroscopy. Intern Med 2021;60:1217-1220. |
| 31 |
Hara Y, Zhang B, Suzuki A, Yamaguchi S, Adachi J, Tomonaga T, Yasunaga S, Saku K, Aoyama T, Hirano K. Effect of tricaprin on cardiac proteome in a mouse model for triglyceride deposit cardiomyovasculopathy. J Oleo Sci. 2020; 69(12):1569-1577. |
| 32 |
Onishi T, Nakano Y, Hirano K, Nagasawa Y, Niwa T, Tajima A, Ishii H, Takahashi H, Sakurai S, Ando H, Takashima H, Amano T. Prevalence and clinical outcomes of triglyceride deposit cardiomyovasculopathy among haemodialysis patients. Heart. 2021; 107(2):127-134. |
| 33 |
Miyauchi H, Iimori T, Hoshi K, Ohyama M, Hirano K, Kobayashi Y. Correlation perspectives for the diagnosis of idiopathic triglyceride deposit cardiomyovasculopathy. Ann Nucl Cardiol 2020; 6(1):33-38. |
| 34 |
Samukawa M, Nakamura N, Hirano M, Morikawa M, Sakata H, Nishino I, Izumi R, Suzuki N, Kuroda H, Shiga K, Saigoh K, Aoki M, Kusunoki S. Neutral Lipid Storage Disease Associated with the PNPLA2 Gene: Case Report and Literature Review. European Neurology 2020; 83(3):317-322. |
| 35 |
Oishi H, Kondo T, Fujimoto K, Mutsuga M, Morimoto R, Hirano K, Sawamura A, Kazama S, Kimura Y, Shibata N, Kato H, Arao Y, Kuwayama T, Yamaguchi S, Hiraiwa H, Okumura T, Usui A, Murohara T. Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device. J Artificial Organs 2020; 23(4):378-382. |
| 36 |
Nakano Y, Suzuki M, Hirano K, Ando H, Takashima H, Takahashi H, Amano T. Association of Triglyceride Deposit Cardiomyovasculopathy With Drug-eluting Stent Restenosis Among Patients With Diabetes. JAMA Network Open 2020; 3(8): e2012583. |
| 37 |
Puluca N, Durmus NG, Lee S, Belbachir N, Galdos FX, Ogut MG, Gupta R, Hirano K, Krane M, Lange R, Wu JC, Wu SM, Demirci U. Levitating Cells to Sort the Fit and the Fat. Adv Biosys 2020;4:e1900300. |
| 38 |
Rajani P, Robertus JL, Wong J, Homfray T, Gil FR, Shanmuganathan M. ATGL Deficiency-Induced Triglyceride Deposit Cardiomyovasculopathy Requiring Heart Transplant A 5-Year Follow-Up. JACC Case Reports 2020; 2:760-763. |
| 39 |
Tanaka M, Ikeda Y, Li M, Zaima N, Kawahara Y, Watanabe K, Inaba T, Kobayashi K, Noguchi H, Yamada S, Hao H, Hirano K. A historical case of primary triglyceride deposit cardiomyovasculopathy. Pathol Int 2020; 70(1):58-61. |
| 40 |
Hirano K, Higashi M, Miyauchi H, Takagi A, Ikeda Y, Nakano Y, Amano T. Increased Washout of 123IBMIPP in Triglyceride Deposit Cardiomyovasculopathy (TGCV) with Severe Coronary Stenosis -A Pitfall of Diagnosis for TGCV-. Ann Nucl Cardiol 2019; 5:47-49. |
| 41 |
Inaba T, Okumura K, Fujita N, Suzuki A, Hirano K. Detection of Jordans’ anomaly using compact-type automated hematology analyzer. Int J Hematol 2019;110:129-130. |
| 42 |
Li M, Hirano K, Ikeda Y, Higashi M, Hashimoto C, Zhang B, Kozawa J, Sugimura K, Miyauchi H, Suzuki A, Hara H, Takagi A, Ikeda Y, Kobayashi K, Futsukaichi Y, Zaima N, Yamaguchi S, Shrestha R, Nakamura H, Kawaguchi K, Sai E, Hui SP, Nakano Y, Sawamura A, Inaba T, Sakata Y, Yasui Y, Nagasawa Y, Kinugawa S, Shimada K, Yamada S, Hao H, Nakatani D, Ide T, Amano T, Naito H, Nagasaka H, Kobayashi K. Triglyceride Deposit Cardiomyovasculopathy: a rare cardiovascular disorder. Orphanet J Rare Dis 2019; 14(1):134. |
| 43 |
Kozawa J, Higashi M, Shimomura I, Hirano K. Intractable Coronary Artery Disease in a Type 2 Diabetic Patient Presenting With Triglyceride Deposit Cardiomyovasculopathy. Diabetes Care 2019; 42(5): 983-986. doi:10.2337/dc18-2365. |
| 44 |
Suzuki A, Yamaguchi S, Li M, Hara Y, Miyauchi H, Ikeda Y, Zhang B, Higashi M, Ikeda Y, Takagi A, Nagasaka H, Kobayashi K, Magata Y, Aoyama T, Hirano K. Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy. J Oleo Sci 2018;67(8):983-989. |
| 45 |
Inaba T, Ishizuka K, Suzuki A, Yuasa S, Saito K, Kodama M, Hongo F, Fujita N, Hirano K. Comparison of neutrophil distribution patterns in Jordans' anomaly among major automated hematology analyzers. Int J Lab Hematol 2018; 40(4):e78-e81. |
| 46 |
Takagi A, Ikeda Y, Kobayashi K, Kobayashi K, Ikeda Y, Kozawa J, Miyauchi H, Li M, Hashimoto C, Hara Y, Yamaguchi S, Suzuki A, Toda T, Nagasaka H, Hirano K. Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy. Biochem Biophys Res Commun 2018;495:646-651. |
| 47 |
Inaba T, Ishizuka K, Suzuki A, Yuasa S, Saito K, Kodama M, Hamada M, Hongo F, Fujita N, Hirano K. Basic utility of Pentra series automated hematology analyzer for screening of Jordans’ anomaly. Int J Lab Hematol 2017:39:e1-e3 |
| 48 |
Shrestha R, Hirano K, Suzuki A, Yamaguchi S, Miura Y, Chen YF, Mizuta M, Chiba H, Hui SP. Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs. Anal Sci 2017; 33(11):1297-1303. |
| 49 |
Higashi M, Hirano K, Kobayashi K, Ikeda Y, Issiki A, Otsuka T, Suzuki A, Yamaguchi S, Zaima N, Hamada S, Hanada H, Suzuki C, Nakamura H, Nagasaka H, Miyata T, Miyamoto Y, Kobayashi K, Naito H, Toda T. Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase. Int J Cardiol 2015;192:30-32. |
| 50 |
Hirano K, Ikeda Y, Sugimura K, Sakata Y. Cardiomyocyte steatosis and defective washout of iodine-123-b-methyliodophenyl-pentadecanoic acid in genetic deficiency of adiposetriglyceride lipase. Eur Heart J 2015; 36:580. |
| 51 |
Ikeda Y, Zaima N, Hirano K, Mano M, Kobayashi K, Yamada S, Yamaguchi S, Suzuki A, Kanzaki H, Hamasaki T, Kotani J, Kato S, Nagasaka H, Setou M, Ishibashi-Ueda H. Coronary triglyceride deposition in contemporary advanced diabetics. Pathol Int 2014;64:325-335. |
| 52 |
Nakanishi T, Kato S. Impact of diabetes mellitus on myocardial lipid deposition: An autopsy study. Pathol Res Pract 2014; 210(12):1018-1025. |
| 53 |
Suzuki A, Nagasaka H, Ochi Y, Kobayashi K, Nakamura H, Nakatani D, Yamaguchi S, Yamaki S, Wada A, Shirata Y, Hui SP, Toda T, Kuroda H, Chiba H, Hirano K. Peripheral leucocyte anomaly detected with routine automated hematology analyzer sensitive to adipose triglyceride lipase deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy. Mol Genet Metab Rep 2014;1:249-253. |
| 54 |
Hara Y, Kawasaki N, Hirano K, Hashimoto Y, Adachi J, Watanabe S, Tomonaga T. Quantitative proteomic analysis of cultured skin fibroblast cells derived from patients with triglyceride deposit cardiomyovasculopathy. Orphanet J Rare Dis 2013;8:197. |
| 55 |
Hirano K, Tanaka T, Ikeda Y, Yamaguchi S, Zaima N, Kobayashi K, Suzuki A, Sakata Y, Sakata Y, Kobayashi K, Toda T, Fukushima N, Ishibashi-Ueda H, Tavian D, Nagasaka H, Hui SP, Chiba H, Sawa Y, Hori M. Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy. Biochem Biophys Res Commun 2014;443:574-579. |
| 56 |
Ikeda Y, Hirano K, Fukushima N, Sawa Y. A novel type of human spontaneous coronary atherosclerosis with triglyceride deposition. Eur Heart J 2014;35:875. |
| 57 |
Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Maeda Y, Hirata E, Fujimura Y, Miura D, Hirano K, Takayanagi R. Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice. Biochem Biophys Res Commun 2013;438:224-229. |
| 58 |
Lin Y, Chiba S, Suzuki A, Yamaguchi S, Nakanishi T, Matsumoto H, Ikeda Y, Ishibashi-Ueda H, Hirano K, Kato S. Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity. Biochem Biophys Res Commun 2013;434:534-540. |
| 59 |
Nakamura K, Hirano K, Wu SM. iPS cell modeling of cardiometabolic diseases. J Cardiovasc Transl Res 2013;6:46-53. |
| 60 |
Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Fujii M, Maeda Y, Fujimura Y, Miura D, Hirano K, Takayanagi R. Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB. J Biol Chem 2011; 286(37):32045-32053. |
| 61 |
Hirano K. A novel clinical entity: triglyceride deposit cardiomyovasculopathy. J Atheroscler Thromb 2009;16:702-705. |
| 62 |
Hirano K, Ikeda Y, Zaima N, Sakata Y, Matsumiya G. Triglyceride deposit cardiomyovasculopathy. N Engl J Med 2008;359:2396-2398. |
