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臨床研究

研究内容・研究成果・論文紹介

英文原著
1 Nagasawa Y, Okumura T, Hara Y, Kondo T, Hasegawa M, Ikeda Y, Murohara T, Hirano K. Genetic deficiency of adipose triglyceride lipase is associated with a novel type of podocythopathy. Kidney International Reports2021;6:2722-2725.
2 Sugawara R, Sugiyama H, Nakamura K, Tohgi K, Hongo T, Tsuchiya M, Momoki N, Nose S, Yutani C, Ikeda Y, Ikeda T, Ito H. Electron Microscopy Revealed Massive Lipid Droplets in Cardiomyocytes in a Patient with Cardiogenic Shock Following a Fulminant Type 1 Diabetes Mellitus. Int Heart J2021; 62(1):197-200.
3 Noguchi H, Yamada S, Hirano K, Yamaguchi S, Suzuki A,Guo X, Zaima N, Li M, Kobayashi K, Ikeda Y, Nakayama T, Sasaguri Y. Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice. Histol Histopathol2021;36:91-100.
4 Nakajima K. Triglyceride depositcardiomyovasculopathy: how torecognise a new disease entity. Heart2020; 107(2):93-95.
5 "Sai E, Shimada K, Aikawa T, Aoshima C, Takamura K, Hiki M, Yokoyama T, Miyazaki T, Fujimoto S, Konishi H, Hirano K, Daida H, Minamino T.Triglyceride Deposit Cardiomyovasculopathy with Massive Myocardial Triglyceride which was Proven UsingProton-magnetic Resonance Spectroscopy. Intern Med2021;60:1217-1220."
6 Hara Y, Zhang B, Suzuki A, Yamaguchi S, Adachi J, Tomonaga T, Yasunaga S, Saku K, Aoyama T, Hirano K. Effect of tricaprin on cardiac proteome in a mouse model for triglyceride deposit cardiomyovasculopathy. J Oleo Sci. 2020; 69(12):1569-1577.
7 Onishi T, Nakano Y, Hirano K, Nagasawa Y, Niwa T, Tajima A, Ishii H, Takahashi H, Sakurai S, Ando H,Takashima H, Amano T. Prevalence and clinical outcomes of triglyceride deposit cardiomyovasculopathy among haemodialysis patients. Heart. 2021; 107(2):127-134.
8 Kobayashi K, Sakata Y, Miyauchi H, Ikeda Y, Nagasawa Y, Shimada K, Nakajima K, Kozawa J, Hao H, Amano T, Yoshida H, Inaba T, Hashimoto C, Hirano K. The Diagnostic Criteria 2020 for Triglyceride Deposit Cardiomyovasculopathy. Ann Nucl Cardiol 2020; 6(1):99-104.
9 Miyauchi H, Iimori T, Hoshi K, Ohyama M, Hirano K, Kobayashi Y. Correlation perspectives for the diagnosis of idiopathic triglyceride deposit cardiomyovasculopathy. Ann Nucl Cardiol 2020; 6(1):33-38.
10 Samukawa M, Nakamura N, Hirano M, Morikawa M, Sakata H, Nishino I, Izumi R, Suzuki N, Kuroda H, Shiga K, Saigoh K, Aoki M, Kusunoki S. Neutral Lipid Storage Disease Associated with the PNPLA2 Gene: Case Report and Literature Review. European Neurology 2020; 83(3):317-322.
11 Oishi H, Kondo T, Fujimoto K, Mutsuga M, Morimoto R, Hirano K, Sawamura A, Kazama S, Kimura Y, Shibata N, Kato H, Arao Y, Kuwayama T, Yamaguchi S, Hiraiwa H, Okumura T, Usui A, Murohara T. Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device. J Artificial Organsy 2020; doi: 10.1007/s10047-020-01184-x
12 Nakano Y, Suzuki M, Hirano K, Ando H, Takashima H, Takahashi H, Amano T. Association of Triglyceride Deposit Cardiomyovasculopathy With Drug-eluting Stent Restenosis Among Patients With Diabetes Mellitus. JAMA Network Opey 2020; 3(8): e2012583."
13 Rajani P, Robertus JL, Wong J, Homfray T, Gil FR, Shanmuganathan M. ATGL Deficiency-Induced Triglyceride Deposit Cardiomyovasculopathy Requiring Heart Transplant A 5-Year Follow-Up. JACC 2020; 2:760-763
14 Tanaka M, Ikeda Y, Li M, Zaima N, Kawahara Y, Watanabe K, Inaba T, Kobayashi K, Noguchi H, Yamada S, Hao H, Hirano K. A historical case of primary triglyceride deposit cardiomyovasculopathy. Pathol Int 2019;70:58-61."
15 Hirano K, Higashi M, Miyauchi H, Takagi A, Ikeda Y, Nakano Y, Amano T. Increased Washout of 123IBMIPP in Triglyceride Deposit Cardiomyovasculopathy (TGCV) with Severe Coronary Stenosis -A Pitfall of Diagnosis for TGCV-. Ann Nucl Cardiol 2019; 5:47-49."
16 Inaba T, Okumura K, Fujita N, Suzuki A, Hirano K. Detection of Jordans’ anomaly using compact-type automated hematology analyzer. Int J Hematol 2019;110:129-130. doi: 10.1007/s12185-019-02689-9
17 Li M, Hirano K, Ikeda Y, Higashi M, Hashimoto C, Zhang B, Kozawa J, Sugimura K, Miyauchi H, Suzuki A, Hara H, Takagi A, Ikeda Y, Kobayashi K, Futsukaichi Y, Zaima N, Yamaguchi S, Shrestha R, Nakamura H, Kawaguchi K, Sai E, Hui SP, Nakano Y, Sawamura A, Inaba T, Sakata Y, Yasui Y, Nagasawa Y, Kinugawa S, Shimada K, Yamada S, Hao H, Nakatani D, Ide T, Amano T, Naito H, Nagasaka H, Kobayashi K. Triglyceride Deposit Cardiomyovasculopathy: a rare cardiovascular disorder. Orphanet J Rare Dis 2019;14:134. doi:10.1186/s13023-019-1087-4."
18 Kozawa J, Higashi M, Shimomura I, Hirano K. Intractable Coronary Artery Disease in a Type 2 Diabetic Patient Presenting With Triglyceride Deposit Cardiomyovasculopathy. Diabetes Care 2019; 42(5): 983-986. doi:10.2337/dc18-2365."
19 Suzuki A, Yamaguchi S, Li M, Hara Y, Miyauchi H, Ikeda Y, Zhang B, Higashi M, Ikeda Y, Takagi A, Nagasaka H, Kobayashi K, Magata Y, Aoyama T, Hirano K. Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy. J Oleo Sci 2018;67(8):983-989."
20 Inaba T, Ishizuka K, Suzuki A, Yuasa S, Saito K, Kodama M, Hongo F, Fujita N, Hirano K. Comparison of neutrophil distribution patterns in Jordans' anomaly among major automated hematology analyzers. Int J Lab Hematoli 2018; 40(4):e78-e81. doi:10.1111/ijlh.12842.
21 Takagi A, Ikeda Y, Kobayashi K, Kobayashi K, Ikeda Y, Kozawa J, Miyauchi H, Li M, Hashimoto C, Hara Y, Yamaguchi S, Suzuki A, Toda T, Nagasaka H, Hirano K. Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy. Biochem Biophys Res Commun 2018;495:646-651.
22 Inaba T, Ishizuka K, Suzuki A, Yuasa S, Saito K, Kodama M, Hamada M, Hongo F, Fujita N, Hirano K. Basic utility of Pentra series automated hematology analyzer for screening of Jordans’ anomaly. Int J Lab Hematoli 2017:39:e1-e3.
23 Higashi M, Hirano K, Kobayashi K, Ikeda Y, Issiki A, Otsuka T, Suzuki A, Yamaguchi S, Zaima N, Hamada S, Hanada H, Suzuki C, Nakamura H, Nagasaka H, Miyata T, Miyamoto Y, Kobayashi K, Naito H, Toda T. Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase. Int J Cardiol2015;192:30-32.
24 Hirano K, Ikeda Y, Sugimura K, Sakata Y. Cardiomyocyte steatosis and defective washout of iodine-123-b-methyliodophenyl-pentadecanoic acid in genetic deficiency of adiposetriglyceride lipase. Eur Heart J2015; 36:580.
25 Ikeda Y, Zaima N, Hirano K, Mano M, Kobayashi K, Yamada S, Yamaguchi S, Suzuki A, Kanzaki H, Hamasaki T, Kotani J, Kato S, Nagasaka H, Setou M, Ishibashi-Ueda H. Coronary triglyceride deposition in contemporary advanced diabetics. Pathol Int 2014;64:325-335.
26 Nakanishi T, Kato S. Impact of diabetes mellitus on myocardial lipid deposition: An autopsy study. Pathol Res Pract 2014;210:1018-1025.
27 Suzuki A, Nagasaka H, Ochi Y, Kobayashi K, Nakamura H, Nakatani D, Yamaguchi S, Yamaki S, Wada A, Shirata Y, Hui SP, Toda T, Kuroda H, Chiba H, Hirano K. Peripheral leucocyte anomaly detected with routine automated hematology analyzer sensitive to adipose triglyceride lipase deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy. Mol Genet Metab Rep 2014;1:249-253.
28 Kaneko K, Kuroda H, Izumi R, Tateyama M, Kato M, Sugimura K, Sakata Y, Ikeda Y, Hirano K, Aoki M. A novel mutation in PNPLA2 causes neutral lipid storage disease with myopathy and triglyceride deposit cardiomyovasculopathy: A case report and literature review. Neuromuscul Disord 2014;24:634-641.
29 Hara Y, Kawasaki N, Hirano K, Hashimoto Y, Adachi J, Watanabe S, Tomonaga T. Quantitative proteomic analysis of cultured skin fibroblast cells derived from patients with triglyceride deposit cardiomyovasculopathy. Orphanet J Rare Dis 2013;8:197.
30 Hirano K, Tanaka T, Ikeda Y, Yamaguchi S, Zaima N, Kobayashi K, Suzuki A, Sakata Y, Sakata Y, Kobayashi K, Toda T, Fukushima N, Ishibashi-Ueda H, Tavian D, Nagasaka H, Hui SP, Chiba H, Sawa Y, Hori M. Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy. Biochem Biophys Res Commun 2014;443:574-579.
31 Ikeda Y, Hirano K, Fukushima N, Sawa Y. A novel type of human spontaneous coronary atherosclerosis with triglyceride deposition. Eur Heart J2014;35:875.
32 Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Maeda Y, Hirata E, Fujimura Y, Miura D, Hirano K, Takayanagi R. Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice. Biochem Biophys Res Commun 2013;438:224-229.
33 Lin Y, Chiba S, Suzuki A, Yamaguchi S, Nakanishi T, Matsumoto H, Ikeda Y, Ishibashi-Ueda H, Hirano K, Kato S. Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity. Biochem Biophys Res Commun 2013;434:534-540.
34 Nakamura K, Hirano K, Wu SM. iPS cell modeling of cardiometabolic diseases. J Cardiovasc Transl Res 2013;6:46-53.
35 Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Fujii M, Maeda Y, Fujimura Y, Miura D, Hirano K, Takayanagi R. Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB. J Biol Chem 2011;286:32045-32053.
36 Hirano K. A novel clinical entity: triglyceride deposit cardiomyovasculopathy. J Atheroscler Thromb 2009;16:702-705.
37 Hirano K, Ikeda Y, Zaima N, Sakata Y, Matsumiya G. Triglyceride deposit cardiomyovasculopathy. N Engl J Med 2008;359:2396-2398.
英文総説
1 Hirano K, Li M, Ikeda Y, Triglyceride Deposit Cardiomyovasculopathy, in: T.H. Oohashi T, Ramirez F, Barber C (Ed.), “Human Pathobiochemistry: from clinical studies to molecular mechanisms”, Springer, Singapore (https://www.springer.com/), 2019;111-119; doi.org/10.1007/978-981-13-2977-7.
2 2. Miyauchi H, Hashimoto C, Ikeda Y, Li M, Nakano Y, Kozawa J, Sai E, Nagasawa Y, Sugimura K, Kinugawa S, Kawaguchi K, Shimada K, Ide T, Amano T, Higashi M, Inaba T, Nakamura H, Kobayashi K, Hirano K. Diagnostic Criteria and Severity Score for Triglyceride Deposit Cardiomyovasculopathy. Ann Nucl Cardiol 2018;4:94-100.
3 3. Higashi M, Ikeda Y, Miyauchi H, Zaima N, Suzuki A, Li M, Kobayashi K, Naito H, Hirano K. Imaging Modalities for Triglyceride deposit cardiomyovasculopathy. Ann Nucl Cardiol 2017;3:94-102.
和総説
1 平野賢一. 【特集インタベ医に知って欲しい新たな冠動脈病変惹起性脂質代謝異常−中性脂肪蓄積心筋血管症(TGCV)−】TGCVの疾患概念とTG蓄積型動脈硬化. Coronary Intervention2021;17:10-16.
2 平野賢一.原発性中性脂肪蓄積心筋血管症.医学のあゆみ2021;277:418-425.
3 東将浩, 平野賢一. 中性脂肪蓄積心筋血管症. 画像診断2021;41(5):428-429.
4 星 佳佑, 宮内 秀行, 平野 賢一, 小林 欣夫. 中性脂肪蓄積心筋血管症の診断に役立つ臨床的因子の検討. 月刊心臓 2020;in press.
5 平野賢一. 中性脂肪蓄積心筋血管症‐この難病を1日でも早く克服する‐ 日本内科学会誌 2017;106:2385-2390.
6 平野賢一 . 中性脂肪蓄積心筋血管症(TGCV). 診断モダリテイーとしての心筋病理 2017:146-147.
7 鈴木 朗,稲葉 亨, 二日市良彰, 平野賢一. 中性脂肪蓄積心筋血管症 (Triglyceride deposit cardiomyovasculopathy, TGCV)における末梢血顆粒球の空胞について —患者の早期発見のためにー. 臨床病理 2017;65:703-711.